George Nicholas Papanicolaou was a pioneer in elucidating the physiology and cytologic characteristics of the female reproductive system. He is best known for creating the Papanicolaou test, commonly known as the Pap smear, which revolutionised the early detection of cervical cancer.
Born on May 13, , in the town of Kimi on the island of Euboea, Greece, Papanicolaou was one of four children. He attended the University of Athens, majoring not in biology, but music and the humanities. However, his physician father influenced his eventual decision to pursue a career in medicine. In , he graduated from medical school with top honours. After graduation, Papanicolaou worked in the military as an assistant surgeon for a short time, then returned to his hometown, Kimi. For the next two years, he cared for leprosy patients on the outskirts of his hometown.
These outcasts were socially isolated, and Papanicolaou gave them both medical and personal care with compassion and grace. However, his desire to work in science soon took hold and he travelled to the University of Munich in Germany, receiving a PhD in zoology in At this leading research institution, he worked with Professor Ernst Haeckel, one of the first great supporters of Darwinism. Shortly thereafter, Papanicolaou married Andromache Mavroyeni Mary , who was from a famous military family.
The young couple returned to Greece following the death of his mother. However, he became interested in career opportunities in the United States US and decided to emigrate, arriving in New York on October 19, Arriving with little money and no arrangements for employment, both Papanicolaou and his wife were forced to take any job that they could get. Mary worked at a department store as a seamstress and Papanicolaou was a rug salesman at the same store, but he lasted only one day.
He subsequently took other jobs: violin player in a restaurant and clerk at a Greek newspaper. In , while studying sex chromosomes, he deduced that reproductive cycles in the experimental animals could be timed by examining smears of their vaginal secretions.
From , he began to focus on the cytopathology of the human reproductive system. He was thrilled when he was able to discern differences between the cytology of normal and malignant cervical cells upon a simple viewing of swabs smeared on microscopic slides.
Although his initial publication of the finding in went largely unnoticed, that year was filled with other happy events for Papanicolaou. As part of his research at the New York Hospital, he collaborated with Dr Herbert Traut, a gynaecological pathologist, eventually publishing their landmark book in , Diagnosis of Uterine Cancer by the Vaginal Smear.
It described physiological changes of the menstrual cycle and the influence of hormones and malignancy on vaginal cytology. Importantly, it showed that normal and abnormal smears taken from the vagina and cervix could be viewed under the microscope and be correctly classified. The simple procedure, now famously known as the Pap smear or test, quickly became the gold standard in screening for cervical cancer. As it cost little, was easy to perform and could be interpreted accurately, the Pap smear found widespread use and resulted in a significant decline in the incidence of cervical cancer.
Papanicolaou was not the first to show that cancerous cells could be identified under the microscope. That honour goes to British physician Walter Hayle Walshe, who referred to this phenomenon in a book on lung diseases one century before. Nor was Papanicolaou the first to study cervical cytopathology in women. However, medical history has sided with Papanicolaou as the originator of the Pap test, as the two methods were viewed to be substantially different.
In , Papanicolaou became Emeritus Professor at what was then Cornell University Medical College, where two laboratories now bear his name. Shortly thereafter, in , he published Atlas of Exfoliative Cytology , a treatise containing comprehensive information on the cytology of both healthy and diseased tissue, not just in the female reproductive system but also in other organ systems. In total, Papanicolaou authored four books and over one hundred articles. He was the recipient of numerous awards, including honorary degrees from universities in the US, Italy and Greece.
His image was featured on the Greek 10,drachma currency note prior to its replacement by the euro and on various Greek stamps. In , the US Postal Service honoured him with a commemorative cent postage stamp. Papanicolaou was a dedicated scientist, as modest as he was hardworking. He did not take vacations, worked seven days a week and relished immersing himself in the wonders of his research. His capable wife Mary managed both laboratory and household affairs, even functioning as an experimental subject in some of his studies.
After nearly 50 years at Cornell, Papanicolaou finally decided in to leave New York to develop and head the Cancer Institute of Miami. Mary was both thrilled and relieved, as she was increasingly concerned over his recent distracted behaviour and fascination with dream analysis and parapsychology.
Unfortunately, Papanicolaou died within three months of his arrival in Miami, suffering a fatal myocardial infarction on February 19, He was 78 years old.
Those of us who looked upon him as a guiding star will always owe him our gratitude, and those women who were helped by his test owe him their lives. National Center for Biotechnology Information , U. Journal List Singapore Med J v. Singapore Med J. Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Carmichael DE. Papanicolaou Society of Cytopathology. George Nicholaus Papanicolaou [online] [Accessed February 19, ].
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